New framework guides safer obesity drug prescribing in older adults

Organized around a series of cases, the framework offers a practical approach to prescribing obesity medications, including GLP-1 medications, that act through gut-derived hormonal pathways to older adults. While these medications offer promising benefits for weight management, glycemic control, and other health conditions, older adults are under-represented in clinical trials. The AGS framework emphasizes that clinicians should carefully consider age-related factors such as sarcopenia and frailty, risk of lean muscle loss, malnutrition, and dehydration.

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American Geriatrics Society

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