Gut immune cells help prevent severe salmonella infections

In a series of tests conducted with mice, the researchers found that the interactions between macrophages and monocytes in the mesentery helped stop salmonella infection from spreading throughout the body.

"Understanding the relationship between macrophages and monocytes in this portion of the gut can help us manipulate immune cells and develop therapies to treat gastrointestinal infections," Kim said.

Jiseon Kim, a postdoctoral research associate in the College of Medicine, is the study's first author. Kiwook Kim is an affiliate of the University of Illinois Cancer Center.

Source:

University of Illinois Chicago

Journal reference:

https://rupress.org/jem/article-abstract/223/6/e20251492/281832/Mesenteric-macrophage-monocyte-circuit-controls?redirectedFrom=fulltext