Norovirus vaccine to be trialled in Scotland as volunteers wanted

Get the latest Daily Record breaking news on WhatsApp

Our community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info

Join us on WhatsApp

A world-first vaccine for the vomiting bug norovirus is being trialled in the UK, with the hope it could cut the “burden on the NHS”, the UK Health Secretary has said.

The new mRNA vaccine from Moderna will enter final stages of testing within the next two weeks, with results so far showing it creates a “strong immune response”.

Experts believe the vaccine could stop people developing the vomiting and diarrhoea bug, which is linked to around 12,000 hospital admissions in the UK every year.

The jab uses mRNA technology to tell the immune system to recognise a “foreign” protein on viruses and mount an attack, in this case targeting three major strains of norovirus.

Dr Patrick Moore, chief investigator of the study and National Institute for Health and Care Research (NIHR) director in the South West, said there were currently “no approved vaccines for norovirus anywhere in the world” and the only treatment available for people with serious illness in hospital is intravenous fluids.

He added: “Norovirus is what we know as the winter vomiting bug, and it’s highly transmissible. It causes vomiting and diarrhoea, usually for two to three days. It can affect people of all ages, and it usually peaks in the winter months in the UK…but we do see norovirus throughout the whole of the year. About one in five cases of gastroenteritis are caused by norovirus – that’s about four million cases annually in the UK and about 685 million globally.”

Join the Daily Record WhatsApp community!

Get the latest news sent straight to your messages by joining our WhatsApp community today.

You'll receive daily updates on breaking news as well as the top headlines across Scotland.

No one will be able to see who is signed up and no one can send messages except the Daily Record team.

All you have to do is click here if you're on mobile, select 'Join Community' and you're in!

If you're on a desktop, simply scan the QR code above with your phone and click 'Join Community'.

We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don’t like our community, you can check out any time you like.

To leave our community click on the name at the top of your screen and choose 'exit group'.

If you’re curious, you can read our Privacy Notice.

Some 27 NHS hospitals and centres in England, Scotland and Wales are taking part in the trial, with some running mobile clinics that could visit care homes or other community sites. Overall, it is hoped 2,500 people in the UK will sign up for the trial before the end of December. Half will receive the vaccine while the other half get a dummy drug.

Everyone in the trial will be followed up for around 25 months, and experts hope the results will show 65% or higher efficacy for the jab.

Moderna will also analyse whether the vaccine should be used as a seasonal jab like the flu vaccine, or whether it could offer lifelong immunity. The firm hopes to file marketing applications in 2026 to have the vaccine approved by health regulators.

Health and Social Care Secretary Wes Streeting said: “Norovirus is highly infectious and puts the NHS under huge strain every winter, costing taxpayers around £100 million a year. The UK is leading the way to develop a world-first vaccine for this vomiting bug, starting with this innovative vaccine trial delivered through the Government-funded National Institute for Health and Care Research.

“Not only is this a huge vote of confidence in the UK’s life sciences sector, but a successful vaccine will help shift our health system away from sickness and towards prevention – reducing pressure on the NHS and keeping people well during the colder months.”

Researchers leading the trial said it would include adults of all ages, though people aged 60 and over are being encouraged to join as they can be badly affected by norovirus. If the vaccine works in adults, the trial is then likely to be extended to children.

The US, Canada and Japan are also taking part in the study, with a possible extension to Australia. Overall, around 25,000 people are expected to be recruited globally.

The vaccine has been engineered to combat three strains of the virus which were responsible for more than two-thirds (67%) of noroviruses cases in 2023/24.

Dr Melanie Ivarsson, chief development officer at Moderna, said: “We are delighted to bring this trial to the UK – by advancing our investigational mRNA norovirus vaccine into a pivotal phase 3 trial, we are one step closer to potentially providing a new tool to prevent infection from this highly contagious virus, which places a significant burden on health systems globally.”

Dr Moore said older adults and immunocompromised patients are usually at higher risk of severe complications and death from norovirus, with about 80 deaths per year in the UK and about 200,000 deaths globally, of which 50,000 are children.

Around two-thirds of outbreaks are in care homes but places such as hospitals, nurseries and schools are also at risk.

Professions that can be badly affected include health and care workers, childcare staff, military personnel, cruise ship employees, flight attendants and food handlers. The new trial is part of the Government’s 10-year strategic partnership with Moderna, which is seeing the firm build a new mRNA research, development and manufacturing facility and investing in UK clinical trials.

Professor Lucy Chappell, NIHR chief executive and chief scientific adviser to the Department of Health and Social Care, said: “This novel vaccine could make a difference to the lives of many – especially our most vulnerable citizens – and reduce the burden of seasonal illness on the NHS.

“Leveraging the UK’s expertise in vaccine development, the DHSC through the NIHR and Moderna are delivering this large-scale trial at pace, so that people across the UK and the world can benefit sooner.”

Don't miss the latest news from around Scotland and beyond. Sign up to our daily newsletter .

Story SavedYou can find this story in  My Bookmarks.Or by navigating to the user icon in the top right.