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College football odds, picks, lines, bets, predictions for Week 6, 2024: Proven model backs Iowa, California

SportsLine's advanced computer model has revealed its 2024 Week 6 college football picks

30 Sep 2024, 11:25 · CBS Sports

The Alabama Crimson Tide were expected to take a slight step back under first-year head coach Kalen DeBoer this season, but they find themselves atop the AP poll heading into the Week 6 college football schedule. They are coming off a dramatic win over then-No. 2 Georgia, and they are 24-point road favorites against Vanderbilt in the Week 6 college football odds via SportsLine consensus. Vanderbilt is coming off back-to-back road losses, but it had an extra week to prepare for this game following its double-overtime loss at then-No. 7 Missouri. Should you back the Commodores has huge underdogs with your Week 6 college football bets?

Other top-five teams playing on Saturday include No. 3 Ohio State (-20.5) vs. Iowa, No. 4 Tennessee (-13.5) at Arkansas, and No. 5 Georgia (-23.5) vs. Auburn. This weekend's top-25 schedule begins on Friday when No. 25 UNLV (-4.5) hosts Syracuse and No. 6 Oregon (-24) faces Michigan State. Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 6

One of the college picks the model is high on during Week 6: Iowa (+20.5) stays within the big spread at No. 3 Ohio State in a 3:30 p.m. ET matchup on Saturday. The Buckeyes are in a letdown spot as they return home following a blowout win at Michigan State last week, and they have a huge game looming against No. 6 Oregon next week. They are facing an Iowa team that enters the week with momentum following comfortable wins over Troy and Minnesota.

Hawkeyes junior running back Kaleb Johnson had a monster game against Minnesota, finishing with 206 rushing yards and three touchdowns on 21 carries. Johnson has racked up at least 119 rushing yards and two touchdowns in all four of his games this season, so Ohio State will have trouble controlling the tempo of Saturday's game. The Buckeyes have only covered the spread twice in their last six games, and SportsLine's model has Iowa covering in over 60% of simulations. See the rest of its Week 6 college football picks here.

Another prediction: California (+11.5) plays a one-score game against No. 8 Miami in a 10:30 p.m. ET kickoff on Saturday. The Hurricanes narrowly avoided a massive upset last week, getting past Virginia Tech in a 38-34 final as 17.5-point favorites. They have now covered the spread just four times in their last 17 conference games, making them a team to fade on the road following that emotional victory.

California had its three-game winning streak snapped in a 19-14 loss at Florida State its last time out, but it had an extra week to recover after that game. Sophomore quarterback Fernando Mendoza has thrown for 892 yards and five touchdowns, with four of his receivers hitting the 100-yard mark. The Golden Bears have won five of their last seven home games, and they are covering the spread in well over 60% of the latest simulations. See picks for every other game in Week 6 here.

How to make college football picks for Week 6

The model has also made the call on who wins and covers in every FBS matchup in Week 6, and it's calling for a whopping seven underdogs to win outright, including an upset in one of the biggest games of the week. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which seven underdogs win outright in Week 6? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.