NFL DFS, Saints vs. Chiefs: Top DraftKings, FanDuel daily Fantasy football picks for Monday Night Football

Daily Fantasy millionaire Mike McClure shares his top NFL DFS picks for New Orleans Saints vs. Kansas City Chiefs on MNF

This was supposed to be the season Patrick Mahomes would be surrounded by top playmakers, boosting his Fantasy football value and appeal for NFL DFS lineups after finishing as QB8 overall and QB11 on a points-per-game basis last season. But injuries have severely weakened that opportunity for Mahomes, who will be without Rashee Rice (knee), Marquise Brown (shoulder) and Isiah Pacheco (leg) in Week 5 when the Kansas City Chiefs play the New Orleans Saints on Monday Night Football (8:15 p.m. ET).. Even without these options, can daily Fantasy football players picture single-game NFL DFS picks without arguably the best QB in the NFL?

The Saints scored more than 40 points in back-to-back games to open the 2024 NFL season, leading the NFL at 45.5 points per game through two weeks. But New Orleans is averaging just 18 ppg over the last two weeks, so how should that drop affect your Monday Night Football NFL DFS strategy? Before setting your NFL DFS lineups on sites like DraftKings and FanDuel for Chiefs vs. Saints, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up.

Now, McClure has turned his attention to Saints vs. Chiefs on Monday Night Football and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Chiefs vs. Saints

One of McClure's top NFL DFS picks for Monday Night Football is Mahomes. The two-time MVP quarterback may be without two of his top playmakers entering the season with Rice (knee) and Pacheco (ankle) out, but Mahomes has been making magic from less-than-elite pass-catchers for the past two seasons en route to back-to-back Super Bowls. 

Head coach Andy Reid knows how to put players in positions to succeed and Mahomes can make any throw to facilitate that. Even if Mahomes' ceiling isn't as high without Rice and some of the other playmakers, he has arguably the highest floor of any quarterback in the NFL.

Part of McClure's optimal NFL DFS strategy also includes stacking Mahomes with Kelce. After a few weeks of feeling like the sky was falling for anyone with Kelce on their Fantasy football teams or spending up for him in NFL DFS lineups, he eased some of those worries with seven receptions for 89 yards last week. The NFL can often be an overreaction league with Fantasy football managers fearing for the worst after a few subpar performances, but Kelce has been arguably the most consistent pass-catcher in the NFL for nearly the last decade. He had seven straight 1,000-yard seasons before finishing with 984 yards last year after missing the first and last game of the season.

Mahomes will likely rely heavily on Kelce with Kansas City playing without many of its other top playmakers. This is the first game Kansas City will be without Rice this season, so McClure expects Kelce to re-assume many of the short and middle-of-the-field targets he's had over the last few seasons as a quality addition to Monday Night Football NFL DFS picks. See who else McClure likes right here. 

How to set Saints vs. Chiefs DFS lineups

McClure is also targeting another undervalued player who could explode for huge numbers on Monday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Chiefs vs. Saints, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.