Monday Night Football prediction, odds, time, spread, line: Chiefs vs. Saints picks from expert on 23-11 run

Danny Vithlani, on a 23-11 run on NFL picks, has revealed his Monday Night Football bets for New Orleans Saints vs. Kansas City Chiefs in Week 5

The Kansas City Chiefs, the two-time defending Super Bowl champions, will look to continue their recent success against the New Orleans Saints when they clash on Monday Night Football. Kansas City has won each of the last three meetings with New Orleans, including a 32-29 win in their last meeting in 2020. The Saints (2-2), who will look to snap a two-game losing streak, are playing against their first AFC foe of the season. The Chiefs (4-0), who are 37-13 (.740) at home since 2018, won their only game against an NFC South opponent this year, defeating the Atlanta Falcons 22-17 on Sept. 22.

The game is slated to start at 8:15 p.m. ET at GEHA Field at Arrowhead Stadium in Kansas City, Mo. After opening at -7.5, Kansas City is now favored by 5.5 points in the latest Chiefs vs. Saints odds via SportsLine consensus, while the over/under for total points scored is 43. NFL underdogs of +5 or more are 17-3-2 ATS this season with 12 outright wins. Before making any Saints vs. Chiefs picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Danny Vithlani, considering his mastery of picks involving the NFL.

Vithlani is coming off a 27-15 debut season on NFL picks with SportsLine, and in 2024 Vithlani has gone 23-11 on his last 34 NFL picks, returning $1,086. Anyone who has followed him is way up.

Now, Vithlani has locked in on Chiefs vs. Saints and just revealed his coveted NFL picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Saints vs. Chiefs:

• Chiefs vs. Saints spread: Kansas City -5.5
• Chiefs vs. Saints over/under: 43 points
• Chiefs vs. Saints money line: Kansas City -242, New Orleans +198
• NO: The Saints have hit the first-half Over in nine of their last 11 away games (+6.70 units)
• KC: The Chiefs have hit the fourth-quarter Under in 17 of their last 19 games (+14.75 units)
• Chiefs vs. Saints picks: See picks at SportsLine
• Chiefs vs. Saints streaming: FuboTV (Try for free)

Why the Chiefs can cover

Quarterback Patrick Mahomes completed 19 of 29 attempts (65.5%) for 245 yards and a touchdown with one interception last week. He is one of two quarterbacks (Geno Smith) with a 65-plus completion percentage and a touchdown pass in each of his first four weeks of the season. Mahomes has a 100-plus rating in two of the past three games at home. He passed for 254 yards and three touchdowns with no interceptions with a 92 rating in the last meeting with the Saints. He has dominated on Monday Night Football, compiling a 6-2 mark with 23 touchdowns (21 passing, two rushing) with six interceptions and a 99.3 rating in eight career starts.

Running back Kareem Hunt totaled 85 yards from scrimmage (69 rushing, 16 receiving) in his season debut last week. He also has played well on Monday Night Football. In six career games on MNF, he has 657 scrimmage yards (109.5 per game) and four TDs (two rushing, two receiving). The eighth-year veteran has played in 92 career games, rushing for 4,505 yards and 40 touchdowns. He also has 228 receptions for 1,906 yards and 17 touchdowns. See who to back at SportsLine.

Why the Saints can cover

Third-year wide receiver Chris Olave leads New Orleans in receptions and yards in 2024. He has 20 catches for 265 yards (13.3 average) and one touchdown. He has two explosive plays of 20 or more yards, including a season-high 39-yarder. He also has 77 yards after the catch and 15 first-down conversions. In the Week 4 loss at Atlanta, he caught eight passes for 87 yards with five first-down conversions.

Defensively, cornerback Alontae Taylor has been a force. He leads New Orleans with 3.5 sacks for 30 yards and is second in tackles with 24, including 18 solo. He has four tackles for loss, four pass breakups and one forced fumble. In the 15-12 loss to the Philadelphia Eagles in Week 3, he registered five tackles, including two solo, with a half-sack and forced fumble. See who to back at SportsLine.

How to make Chiefs vs. Saints picks

Vithlani has analyzed Saints vs. Chiefs from every possible angle. He's leaning Under the total and has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is, and which team to back, at SportsLine. 

So who wins Saints vs. Chiefs on Monday Night Football, and what critical x-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Saints vs. Chiefs spread to back, all from the expert who is 23-11 on NFL picks, and find out.