2024 college football picks, Week 6 odds, lines, best bets from proven expert: This 3-leg parlay pays 6-1

Thomas Casale has locked in his top three college football picks for Week 6 and his CFB parlay could pay out around +600

The Week 6 college football schedule only features one ranked vs. ranked matchup, but that game could have College Football Playoff implications. No. 9 Missouri is a 2.5-point road underdog at No. 25 Texas A&M, as the Tigers get set for their first road game of the season. The Aggies have jumped back into the polls after rattling off four consecutive wins, but they have only covered the spread once in their last eight games. Missouri has been a profitable team dating back to last season (11-4 ATS), so should you back the Tigers with your Week 6 college football bets?

Three teams ranked inside the top 11 will be going on the road in primetime on Saturday night, including No. 10 Michigan (+1.5) at Washington in a national championship rematch. Elsewhere, No. 11 USC (-8) travels to Minnesota, while No. 8 Miami (-10) heads to California. Before locking in any Week 6 college football picks, be sure to see the top Week 6 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games -- all publicly documented. Anybody who has followed him is way up.

Now, he has turned his attention to the Week 6 college football odds and is sharing his top three best bets. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 6 college football expert predictions

One of Casale's top Week 6 college football picks: He is backing Stanford (+7.5) to cover at home against Virginia Tech in an ACC matchup at 3:30 p.m. ET on Saturday. Virginia Tech is coming off a pair of crushing losses, falling to Rutgers by three points at home before letting a late lead slip away against then-No. 7 Miami last week. The Hokies had a Hail Mary touchdown overturned on the final play against the Hurricanes, and now they have to travel across the country for this game.

Stanford is making its ACC home debut after splitting a pair of road games against Syracuse and Clemson. The Cardinal are led by running back Micah Ford, who has the most rushing yards (169) in conference play among players who have played in two ACC games. Casale expects Virginia Tech's emotionally draining loss last week to play a major role in the outcome of this game, so he is backing Stanford to cover as a home underdog. See what other picks Casale likes at SportsLine. 

How to make Week 6 college football picks 

Casale has also found two other college football picks he loves, including backing another underdog he says will cover and "potentially win outright." You can only see his picks at SportsLine.

What are the best bets for Week 6 of college football, and which underdog should you be all over? Visit SportsLine now to see Thomas Casale's college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.