Monday Night Football odds, line, time, spread: Jaguars vs. Bills picks from Jacksonville expert on 41-18 run

Mike Tierney, who is 41-18 on Jacksonville picks, has revealed his Monday Night Football doubleheader best bets for Buffalo vs. Jacksonville

The Jacksonville Jaguars (0-2) will visit the Buffalo Bills (2-0) in a primetime battle as part of a Monday Night Football doubleheader. These AFC foes have had different starts to begin 2024. The Bills are rolling offensively, scoring 30-plus in back-to-back games. In Week 2, Buffalo blew out the Miami Dolphins, 31-10. Meanwhile, the Jaguars have yet to score more than 20 points. The Cleveland Browns beat Jacksonville, 18-13, in Week 2.

Kickoff from at Highmark Stadium in Buffalo, NY., is set for 7:30 p.m. ET. Buffalo is a 5.5-point favorite in the latest Jaguars vs. Bills odds via SportsLine consensus, while the over/under for total points scored is 45.5. Before locking in any Bills vs. Jaguars picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Mike Tierney.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Mike is 154-124-9 in the NFL the past two seasons, returning $1,586 to $100 players. Tierney also has a strong read on the Jags. In fact, he is 41-18 (+2161) on his last 59 NFL picks in games involving Jacksonville. Anyone who has followed him is way up.

Now, Tierney has locked in on Jaguars vs. Bills and just revealed his coveted NFL picks and sports betting predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Bills vs. Jaguars:

• Jaguars vs. Bills spread: Buffalo -5.5
• Jaguars vs. Bills over/under: 45.5 points
• Jaguars vs. Bills money line: Buffalo -250, Jacksonville +203
• BUF: Bills have hit the 2Q money line in 10 of their last 19 games
• JAX: Jaguars have covered the 1H spread in 13 of their last 21 games
• Jaguars vs. Bills picks: See picks at SportsLine

Why the Bills can cover

The Bills' offense is revamped this year, but they have a strong group of pass-catchers. Receiver Khalil Shakir is a sound route-runner who has plenty of body control to win on multiple levels. In two games, the Boise State product has eight catches for 96 yards and one touchdown. Shakir has logged 40-plus yards in consecutive games.

Receiver Keon Coleman is a physical playmaker. Coleman owns the verticality to rise above defenders to make tough grabs. The Florida State product has reeled in four catches for 51 yards. Running back James Cook is also a weapon as a pass-catcher. The Georgia product sneaks out of the backfield to give Buffalo a safety valve. He has four grabs for 49 yards. See who to back at SportsLine.

Why the Jaguars can cover

Jacksonville has a solid group of pass-catchers. Rookie receiver Brian Thomas Jr. has the speed to be a viable vertical threat. The LSU product is leading the team in receiving yards (141) with six receptions and one score. In his last contest, Thomas Jr. had four catches for 94 yards.

Receiver Gabe Davis came over in the offseason as a free agent. He is another player who can help push the ball downfield and track the deep ball well. The UCF product is second on the team in receiving yards (105) with six receptions. He's totaled 40-plus receiving yards in back-to-back games. See who to back at SportsLine.

How to make Jaguars vs. Bills picks

Tierney has analyzed Bills vs. Jaguars from every possible angle and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is at SportsLine. 

So who wins Bills vs. Jaguars on Monday Night Football, and what critical x-factor makes one side hit hard? Visit SportsLine now to see which side of the Bills vs. Jaguars spread to back, all from the expert who is 41-18 on picks involving Jacksonville, and find out.