In a mouse model of tauopathy, conventional type 1 dendritic cells (cDC1s) cross-presented brain-derived antigens in deep cervical lymph nodes, priming CD8+ T cells that accumulated in the brain and promoted neurodegeneration. Disrupting cDC1s or their cross-presentation activity reduced CD8+ T-cell infiltration and protected against neuronal loss, while human primary tauopathy samples also showed increased brain CD8+ T cells, although cDC1 involvement in humans remains unconfirmed.

Beneath the rocky slopes of Mount Timpanogos lies far more ice than anyone walking across the surface might suspect. Researchers used gravity measurements to map the buried glacier in 3D and found it is about 83% ice, with enough frozen water to fill 600 Olympic swimming pools. Their findings suggest rock glaciers form as falling debris buries persistent snow and preserves it for thousands of years. Similar formations around the world may collectively store tens of gigatons of hidden water.

Beneath the rocky slopes of Mount Timpanogos lies far more ice than anyone walking across the surface might suspect. Researchers used gravity measurements to map the buried glacier in 3D and found it is about 83% ice, with enough frozen water to fill 600 Olympic swimming pools. Their findings suggest rock glaciers form as falling debris buries persistent snow and preserves it for thousands of years. Similar formations around the world may collectively store tens of gigatons of hidden water.