Photothermal Spectroscopy Corp. launches stRAMos™ — A breakthrough SRS, Stimulated Raman microscope based on photothermal detection
by Photothermal Spectroscopy Corp · News-MedicalPhotothermal Spectroscopy Corp. today announced the release of stRAMos™, a next-generation Raman microscope based on photothermal detection of Stimulated Raman scattering, or SRS. This new system delivers unmatched speed, sensitivity, spatial resolution, and multimodal imaging capabilities for life science and materials research.
The stRAMos microscope introduces a 10x sensitivity improvement over conventional SRS techniques, achieving sub-300 nm spatial resolution and enabling ultrafast hyperspectral imaging with laser tuning speeds as fast as 25 ms per wavenumber. This breakthrough performance is powered by PhotoThermalSRS™ or PT-SRS, which detects the photothermal signal generated during stimulated Raman scattering - unlocking new levels of chemical contrast and experimental flexibility.
Key features of stRAMos™ include:
- Up to 10,000 times faster than confocal Raman microscope (for a single band).
- Up to 10x higher sensitivity than SRS microscopy.
- ≤300 nm spatial resolution for high-definition chemical imaging.
- Real-time, label-free live-cell and sub-cell imaging.
- 3D volumetric imaging with sub-micron axial resolution.
- Multimodal integration with O-PTIR, fluorescence microscopy, and spontaneous Raman spectroscopy.
- Robust, user-friendly design with no manual laser alignment required.
The platform’s multimodal capabilities uniquely allow researchers to combine PT-SRS with Optical Photothermal Infrared Spectroscopy (O-PTIR) and fluorescence microscopy, enabling comprehensive correlative chemical analysis within a single system.
Applications of stRAMos include:
- Live-cell characterization.
- Label-free tissue imaging with depth profiling.
- Biomolecular structure analysis.
- Advanced life science and materials research.
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