Early neural activity regulates speech-related gene to build communication circuits

Using advanced activity tagging, live neural recording, and circuit manipulation techniques, the NYCU team identified a previously underappreciated communication circuit linking the ventromedial prefrontal cortex (vmPFC) and the striatum. Neurons in this circuit became highly active immediately before vocalizations, suggesting the pathway contributes to the initiation or regulation of vocal communication. The finding shifts attention beyond traditional brainstem vocal centers and highlights a higher-order forebrain circuit involved in early communication development.

Dr. Shih-Yun Chen, first author, Institute of Neuroscience at NYCUWe found that early neural activity does not merely accompany vocalization; it contributes to the maturation of communication circuits. This suggests that communication-related brain networks are dynamically refined during development through interactions between neural activity and gene regulation."

The NYCU team further showed that activating this circuit increased Foxp2 expression, a gene often described as speech-related because mutations in humans are linked to childhood apraxia of speech and other communication impairments. Increased neural activity also promoted the formation of synaptic connections within developing corticostriatal pathways that integrate emotional, sensory, and motor information. Importantly, stimulating the circuit during development partially restored vocal deficits in mice with a Foxp2 mutation. The findings do not suggest a therapy but indicate that communication-related circuits may remain biologically responsive early in development. Rather than acting solely as a static developmental gene, Foxp2 may participate in activity-dependent plasticity and be dynamically regulated by neural activity during critical developmental windows.

Although the study was conducted in rodent models, these findings offer a new way to understand how higher-order forebrain circuits lay the foundations for communication in early life. The work may provide a biological framework for studying how early disruptions in brain development are associated with later speech and social communication difficulties, and why early brain development may present important opportunities for support and intervention.

Source:

National Yang Ming Chiao Tung University

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