Head to Head Review: Ultragenyx Pharmaceutical (NASDAQ:RARE) versus Seer (NASDAQ:SEER)
by Jessica Moore · The Cerbat GemUltragenyx Pharmaceutical (NASDAQ:RARE – Get Free Report) and Seer (NASDAQ:SEER – Get Free Report) are both medical companies, but which is the better business? We will contrast the two businesses based on the strength of their institutional ownership, risk, analyst recommendations, dividends, valuation, earnings and profitability.
Analyst Ratings
This is a summary of current ratings and price targets for Ultragenyx Pharmaceutical and Seer, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Ultragenyx Pharmaceutical | 1 | 2 | 14 | 1 | 2.83 |
| Seer | 1 | 0 | 0 | 2 | 3.00 |
Ultragenyx Pharmaceutical presently has a consensus target price of $60.41, suggesting a potential upside of 124.96%. Seer has a consensus target price of $4.00, suggesting a potential upside of 119.18%. Given Ultragenyx Pharmaceutical’s higher probable upside, research analysts clearly believe Ultragenyx Pharmaceutical is more favorable than Seer.
Risk and Volatility
Ultragenyx Pharmaceutical has a beta of 0.39, suggesting that its share price is 61% less volatile than the S&P 500. Comparatively, Seer has a beta of 1.63, suggesting that its share price is 63% more volatile than the S&P 500.
Profitability
This table compares Ultragenyx Pharmaceutical and Seer’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Ultragenyx Pharmaceutical | -91.03% | -1,024.42% | -45.78% |
| Seer | -443.96% | -26.04% | -23.10% |
Earnings & Valuation
This table compares Ultragenyx Pharmaceutical and Seer”s top-line revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Ultragenyx Pharmaceutical | $673.00 million | 3.93 | -$575.00 million | ($6.11) | -4.40 |
| Seer | $16.12 million | 6.39 | -$73.60 million | ($1.28) | -1.43 |
Seer has lower revenue, but higher earnings than Ultragenyx Pharmaceutical. Ultragenyx Pharmaceutical is trading at a lower price-to-earnings ratio than Seer, indicating that it is currently the more affordable of the two stocks.
Institutional & Insider Ownership
97.7% of Ultragenyx Pharmaceutical shares are owned by institutional investors. Comparatively, 75.2% of Seer shares are owned by institutional investors. 5.2% of Ultragenyx Pharmaceutical shares are owned by company insiders. Comparatively, 11.3% of Seer shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.
Summary
Seer beats Ultragenyx Pharmaceutical on 10 of the 15 factors compared between the two stocks.
About Ultragenyx Pharmaceutical
Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Latin America, Japan, Europe, and internationally. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the treatment of children and adults with Mucopolysaccharidosis VII; Dojolvi for treating long-chain fatty acid oxidation disorders; and Evkeeza (evinacumab) for the treatment of homozygous familial hypercholesterolemia. The company's products candidatures include DTX401, an adeno-associated virus 8 (AAV8) gene therapy clinical candidate for the treatment of patients with glycogen storage disease type Ia; DTX301, an AAV8 gene therapy for the treatment of patients with ornithine transcarbamylase; UX143, a human monoclonal antibody for the treatment of osteogenesis imperfecta; GTX-102, an antisense oligonucleotide for the treatment of Angelman syndrome; UX111, an AAV9 gene therapy product candidate for the treatment of patients with Sanfilippo syndrome type A, or MPS IIIA, a rare lysosomal storage disease; UX701, for the treatment of Wilson disease; and UX053 for the treatment of glycogen storage disease type III. Ultragenyx Pharmaceutical Inc. has collaboration and license agreement with Kyowa Kirin Co., Ltd.; Saint Louis University; Baylor Research Institute; REGENXBIO Inc.; Bayer Healthcare LLC; GeneTx; Mereo; University of Pennsylvania; Arcturus Therapeutics Holdings Inc.; Solid Biosciences Inc.; Regeneron; Abeona; and Daiichi Sankyo Co., Ltd. The company was incorporated in 2010 and is headquartered in Novato, California.
About Seer
Seer, Inc., a life sciences company, engages in developing and commercializing products to decode the biology of the proteome. It develops Proteograph Product Suite, an integrated solution that includes proprietary engineered nanoparticles, consumables, automation instrumentation, and software to perform proteomic analysis to provide a solution that can be incorporated by nearly any lab for research use only. The company intends to sell its products for research use only, which cover academic institutions, life sciences, and research laboratories, as well as biopharmaceutical and biotechnology companies for non-diagnostic and non-clinical purposes. It operates in China, Australia, Eastern Europe, Israel, and Japan. The company was formerly known as Seer Biosciences, Inc. and changed its name to Seer, Inc. in July 2018. Seer, Inc. was incorporated in 2017 and is headquartered in Redwood City, California.