Where 9/11 responders live may influence frailty, PTSD and depression decades later
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Twenty-five years after the September 11 terrorist attacks, researchers at the Icahn School of Medicine at Mount Sinai have found that environmental conditions where World Trade Center responders live may influence their long-term physical and mental health.
Published in Nature Communications, the study found an association between responders exposed to higher temperatures and greater levels of air pollution and an increased risk of frailty, post-traumatic stress disorder (PTSD) and depression as they aged. In contrast, living in greener environments was associated with lower risks of all three conditions.
The study, "Urban Exposures, Frailty, and Mental Illness in World Trade Center Health Program Responders," is the first to examine how later-life environmental exposures may interact with World Trade Center-related chemical and psychological exposures to affect aging and mental health outcomes.
"Twenty-five years after 9/11, we are still learning about the factors that influence the health of those who responded to the attacks," says Helena Furman Krasnov, Ph.D., a postdoctoral researcher at the Icahn School of Medicine and first author of the study. "Our findings suggest that everyday exposures, including heat, air pollution and access to green space, may contribute to responders' long-term physical and psychological well-being. Understanding these factors could help identify new opportunities to support healthy aging in this population."
Neighborhood stressors add to trauma
World Trade Center responders experienced a unique combination of toxic exposures and extreme psychological stress following the attacks. While previous research has linked those exposures to a range of long-term health conditions, less was known about how neighborhood environments might shape health decades later.
For the study, researchers analyzed data from 18,734 responders who live in New York City and are enrolled in one of the World Trade Center Health Clinical Centers of Excellence. They evaluated annual exposure to air pollution, high temperatures and neighborhood greenness and examined associations with frailty, PTSD and depression.
The researchers found that responders living in hotter and more polluted environments faced greater risks of frailty and mental health conditions. They also found that responders with higher levels of World Trade Center-related chemical and psychological exposure appeared more vulnerable to these environmental stressors. By contrast, greener surroundings were associated with lower risks of frailty, PTSD and depression.
"Our findings suggest that the health consequences of 9/11 may not end with the disaster itself," says Maayan Yitshak-Sade, MPH, Ph.D., associate professor of environmental medicine at the Icahn School of Medicine, senior and corresponding author of the study, and a member of Mount Sinai's Institute for Exposomic Research. "For responders already carrying the biological effects of trauma and toxic exposures, everyday environmental conditions may represent an additional source of stress on the body and mind. These findings highlight the importance of considering where people live, not just what they experienced during the disaster."
Lessons for future disaster survivors
The researchers say the findings may have implications beyond the World Trade Center responder community. People affected by disasters such as wildfires, industrial accidents and building collapses may face similar combinations of physical and psychological exposures that continue to influence health long after the initial event.
The team plans to further investigate whether beneficial environmental factors, including green space and access to healthy foods, can help reduce the long-term health effects associated with World Trade Center-related exposures.
Publication details
Urban Exposures, Frailty, and Mental Illness in World Trade Center Health Program Responders, Nature Communications (2026). DOI: 10.1038/s41467-026-77401-7
Journal information: Nature Communications
Key medical concepts
Post-Traumatic Stress DisorderFrailty
Clinical categories
PsychiatryPsychology & Mental healthGeriatric palliative careHealthy agingOccupational medicine Provided by The Mount Sinai Hospital Who's behind this story?
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