Coffee appears to change how the gut functions
· Medical Xpressedited by Sadie Harley, reviewed by Robert Egan
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If you drink coffee regularly, it appears to alter not only your gut bacteria but also the physiology of the gut itself. That is the conclusion of a study from the University of Copenhagen, which may help point the way toward better treatments for constipation. The study is published in the journal Gut Microbiology.
A research team from the University of Copenhagen asked a group of Danish participants to swallow a small electronic capsule. As it traveled through the digestive tract, the capsule measured, among other things, transit time through the gastrointestinal system, temperature, pH levels and intestinal contractions.
The participants, 61 healthy Danish adults, were categorized into frequent coffee drinkers, defined as consuming between one and five cups a day on more than three of the eight study days, and those who drank coffee less often.
The results first and foremost confirmed that coffee affects the composition of gut bacteria, as previous studies have suggested. Frequent coffee drinkers had a greater diversity of microorganisms in their gut than those who drank coffee less often.
"But perhaps more importantly, frequent coffee consumption appears to affect the physiology of the gut itself, in other words, how the gut functions," says first author Francesca Bucci, a Ph.D. student at the Department of Nutrition, Exercise and Sports at the University of Copenhagen.
It is already well established that moderate coffee consumption is associated with a reduced risk of cardiovascular disease, diabetes, depression and several types of cancer. However, much less is known about how habitual coffee consumption relates to physiological conditions within the gut.
Stimulates contractions in the gut
The researchers found that frequent coffee drinkers had a significantly lower pH in the small intestine than those who drank coffee less often. They also observed that higher coffee consumption was associated with more contractions in the colon.
So are these physiological differences beneficial or not?
"Contractions in the gut can support healthy digestion, help prevent constipation and keep the intestinal muscles in good condition," says Bucci.
The researchers cannot yet determine whether the lower pH is beneficial or harmful to health. However, the pH level in the small intestine plays an important role in the activity of digestive enzymes and in how food is broken down.
The researchers also stress that the study cannot establish whether the differences are caused solely by coffee consumption. Nevertheless, senior author Henrik Munch Roager believes there is good reason to think coffee plays a key role.
"For example, we already know from other studies that coffee can influence a range of processes in the digestive system, including acid secretion in the stomach. So there are good reasons to believe that what we are seeing is not merely coincidence. Anecdotally, many people also report that coffee affects their digestion," says Roager, associate professor and research group leader at the Department of Nutrition, Exercise and Sports.
Calls for further studies
According to Roager, the natural next step would be an intervention study in which researchers control how much coffee participants drink and examine what happens to gut physiology during periods of high coffee consumption compared with periods without coffee.
The researchers hope that these and future findings can help address a widespread problem.
"A great many people struggle with constipation and irregular bowel movements. If we can understand how coffee affects digestion and intestinal contractions, it may be possible to use that knowledge to stimulate gut motility in a natural way. That would be extremely valuable," says Roager.
More information
Francesca Bucci et al., Habitual coffee consumption is linked to differences in gut microbiota and gut physiology, Gut Microbiology (2026). DOI: 10.1016/j.gutmic.2026.100018
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GastroenterologyDigestive healthNutrition & Healthy eatingHealthy living Provided by University of Copenhagen Who's behind this story?
Sadie Harley
BSc Life Sciences & Ecology. Microbiology lab background with pharmaceutical news experience in oil, gas, and renewable industries. Full profile →
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