Metabolic dysfunction-associated steatotic liver disease linked to higher odds of eosinophilic esophagitis
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Metabolic dysfunction-associated steatotic liver disease (MASLD) is significantly associated with eosinophilic esophagitis (EoE), according to a study published online July 22 in the Journal of Gastroenterology and Hepatology.
Rishi Chowdhary, M.D., from Case Western Reserve University in Cleveland, and colleagues used the TriNetX U.S. Collaborative Network database to identify adult patients with and without MASLD. The associations of MASLD with EoE and gastroesophageal reflux disease (GERD) were examined. After propensity matching, the analysis included 266,980 patients ages 18 to 44; 385,138 patients ages 45 to 64; and 150,640 patients ages 65 and older.
The researchers found that MASLD was strongly associated with increased odds of EoE across all age groups (ages 18 to 44: odds ratio, 2.905; ages 45 to 64: odds ratio, 2.423; ages 65 and older: odds ratio, 2.327). Similarly, there were significantly higher odds of GERD, nonerosive reflux disease, erosive esophagitis and Barrett's esophagus among patients with MASLD across all age groups.
"As MASLD prevalence continues to rise globally, clinicians should maintain increased vigilance for esophageal complications in this population," the authors write. "Future prospective studies are needed to clarify causal mechanisms and determine whether targeted metabolic interventions can mitigate esophageal disease risk."
More information
Rishi Chowdhary et al, Burden of Eosinophilic Esophagitis and Gastroesophageal Reflux Disease in Metabolic Dysfunction–Associated Steatotic Liver Disease: A Comprehensive US Healthcare Analysis, Journal of Gastroenterology and Hepatology (2026). DOI: 10.1111/jgh.70609
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Citation: Metabolic dysfunction-associated steatotic liver disease linked to higher odds of eosinophilic esophagitis (2026, July 31) retrieved 1 August 2026 from https://medicalxpress.com/news/2026-07-metabolic-dysfunction-steatotic-liver-disease.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.