Lower vertebral bone mineral density linked to cognitive decline

30 Sep 2026, 23:40 · Medical Xpress

by Lori Solomon

edited by Sadie Harley, reviewed by Alexander Pol

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Lower vertebral bone mineral density (vBMD) is associated with changes in brain structure and cognition among older adults, according to a study published online in Radiology.

Sara Momtazmanesh, M.D., from Johns Hopkins University in Baltimore, and colleagues examined whether thoracic vBMD, derived using deep learning models of noncontrast chest computed tomography (CT), is associated with longitudinal changes in white matter (WM) integrity, WM hyperintensities (WMH) burden and cognitive decline.

The analysis included 715 adults (median age, 69 years) without clinically recognized cardiovascular disease who were participating in the Multi-Ethnic Study of Atherosclerosis.

The researchers found that lower baseline vBMD was associated with faster decline in total WM fractional anisotropy (405 participants; β = −0.036 standard deviation [SD]/year/0.1 g/cm³ vBMD decrease). However, this association did not survive false discovery rate correction.

Lower vBMD was associated with faster fractional anisotropy decline in the anterior limb of the internal capsule (β = −0.048 SD/year) and faster WMH accumulation in the corpus callosum (408 participants; β = 12.8%/year). Lower vBMD also was associated with faster decline in the global cognitive composite (639 participants; β = −0.025 SD/year) and the Cognitive Abilities Screening Instrument (675 participants; β = −0.320/year). Diabetes intensified the associations with WMH progression (β = 4.99%).

"Chest CT is done for lung cancer screening, calcium scoring, nodule follow-up, and many other indications," Momtazmanesh said in a statement. "These scans could provide an opportunistic measurement of bone density from the thoracic spine that is associated with a loss of cognitive function."

Publication details

Sara Momtazmanesh et al, Deep Learning–derived Bone Mineral Density and Longitudinal White Matter Microstructure and Cognitive Decline: Multi-Ethnic Study of Atherosclerosis, Radiology (2026). DOI: 10.1148/radiol.260656

Journal information: Radiology

Key medical concepts

Cognitive DeclinesHyperintensity of cerebral white matter on MRI

Clinical categories

NeurologyDiagnostic radiologyHealthy aging Who's behind this story?

Sadie Harley

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