Hyperuricemia predicts mortality with chronic kidney disease

by Lori Solomon

edited by Gaby Clark, reviewed by Alexander Pol

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Hyperuricemia independently predicts mortality in chronic kidney disease (CKD), according to a study published online July 13 in the Journal of Clinical Medicine.

Rasha Babiker, M.B.B.S., Ph.D., from Ras Al Khaimah Medical and Health Sciences University in the United Arab Emirates, and colleagues assessed whether hyperuricemia has prognostic significance for adverse outcomes in CKD. The analysis included 794 patients with CKD.

The researchers found that hyperuricemia was present in 44.8% of patients. There was a trend toward an association between hyperuricemia and increased odds of cardiac events (odds ratio [OR], 1.49; 95% confidence interval [CI], 0.98 to 2.27; P = 0.061). Hyperuricemia independently predicted mortality (OR, 1.98; 95% CI, 1.04 to 3.78; P = 0.039).

There was also a dose-response relationship between serum uric acid and adverse outcomes, with each 100-μmol/L increase in serum uric acid associated with increased cardiac event risk (OR, 1.22; 95% CI, 1.05 to 1.42; P = 0.011) and increased mortality risk (OR, 1.29; 95% CI, 1.09 to 1.53; P = 0.004). Patients in the highest uric acid quartile had more than threefold higher mortality than those in the lowest quartile (OR, 3.13; 95% CI, 1.26 to 7.79; P = 0.014).

"This study suggests that serum uric acid behaves as a graded marker of systemic vulnerability rather than a simple binary risk factor, with progressively higher concentrations associated with higher mortality risk," the authors write.

More information

Rasha Babiker et al, Serum Uric Acid and Mortality Risk in Chronic Kidney Disease: A Dose–Response Analysis, Journal of Clinical Medicine (2026). DOI: 10.3390/jcm15145479

Key medical concepts

HyperuricemiaChronic Kidney DiseaseMortality

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Nephrology Who's behind this story?

Gaby Clark

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