Experiences reshape brain cell connections, synapse mapping reveals
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Experiences and changes in the environment cause widespread alterations in connections between brain cells, influencing brain activity, research suggests. Using a novel technology to map and study billions of individual brain cell connections, scientists have found that mice exposed to an enriched environment showed changes in different populations of synapses—the connections through which nerve cells communicate—across many brain regions.
The study is published in the journal Nature Communications.
Distinct synapse types responded differently to environmental influences, with some increasing or decreasing in number, while others remained unchanged. Understanding these patterns could help to pinpoint why some events can support the brain to adapt, while others may contribute to impaired function, experts say.
Synapse changes have previously been linked to sleep deprivation, brain injury and genetic variants associated with autism, schizophrenia and other disorders.
Alterations to the brain's diverse synapse populations could be a common mechanism through which it adapts to both inherited and environmental influences, the research team suggests.
Understanding how experiences influence brain activity could point to potential interventions to modify synapse populations that may have been disrupted by environmental and genetic factors or injury, they add.
Mapping connections across the brain
Scientists have long known that experience changes the brain. Learning and sensory input can alter the strength of communication between nerve cells, and synapses can form, disappear or change their structure.
Previous studies have concentrated on relatively small numbers of synapses in localized areas, providing a limited view of how experience changes synapse populations across the brain.
The University of Edinburgh–led research team used synaptome mapping—a technology combining high-resolution microscopy with automated image analysis—to look at brain cell connections across the whole mouse brain.
The team studied mice exposed to enriched environments—containing running wheels, changing mazes and greater opportunities for social interaction—both during development and in adulthood.
They found the overall density of synapses in the brain did not increase, indicating the quality and type of synaptic connections are more important than the quantity when it comes to brain changes, researchers say.
Vision changes reach beyond sight
To explore the impact of sensory changes across the brain, scientists studied mice that had one eye closed for one week. Altering vision in one eye led to synapse changes beyond the parts of the brain linked to sight, including areas involved in other senses and memory.
The findings suggest that changes affecting one sensory experience can lead to widespread molecular adaptations in the brain, underlining the complex interconnectivity of brain functions, experts say.
The research team included scientists from Cardiff University and the University of Strathclyde.
Questions for brain health and development
Dr. Hanan Woods, first author of the study from the University of Edinburgh's Institute for Neuroscience and Cardiovascular Research, said, "Our findings suggest that sensory and environmental experiences reshape the molecular landscape of synapses throughout the brain. This diversity and capacity for adaptation may provide an important foundation for understanding the brain's resilience and vulnerability to disease throughout life."
Seth Grant, professor of molecular neuroscience at the University of Edinburgh, said, "For development and education, the findings raise questions about how different combinations of sensory, physical, social and learning experiences shape the molecular architecture of the brain.
"The work provides a basis for future questions about how our environment, social interactions and experiences such as prolonged phone or tablet use modify the brain."
Publication details
Nature Communications (2026) DOI: 10.1038/s41467-026-78702-7. www.nature.com/articles/s41467-026-78702-7
Journal information: Nature Communications
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Sadie Harley
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