Up to 45% of dementia risk can be prevented, delayed: WHO

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Up to 45 percent of dementia risk could be prevented or delayed, the World Health Organization said Wednesday, citing modifiable risk factors such as tobacco use and air pollution.

Dementia is the seventh-leading cause of death and a major cause of disability and dependency among older people globally.

Dementia is caused by brain diseases and affects memory, thinking and the ability to function.

"While there is no cure for dementia, up to 45 percent of the risks can be attributed to modifiable risk factors such as tobacco, alcohol use, social isolation, physical inactivity, air pollution and noncommunicable diseases (NCDs), including high blood pressure and diabetes," the WHO said in a statement.

More than 57 million people live with dementia worldwide, and nearly 10 million people are diagnosed every year, it said.

Alzheimer's disease is the most common form of dementia and is estimated to account for 60 to 70 percent of cases.

"Behind these numbers are individuals, families, and communities navigating profound challenges that affect not only health, but dignity, independence, and well-being," said Devora Kestel, director of the WHO's NCDs and mental health department.

"This is not a distant issue; it touches all of us," she wrote in a foreword to updated WHO guidance published Wednesday on how health workers and policymakers can help prevent or delay the onset of dementia.

The U.N. health agency issued its first dementia recommendations in 2019 but said the evidence base had grown significantly since then.

The guidelines aim to promote early awareness and intervention in a bid to reduce the burden of dementia in the coming decades, it said.

Although more common after 65, the condition is not an inevitable part of aging, the WHO said.

Focus on prevention

"We know more today than ever before about what drives dementia risk, and these guidelines translate that knowledge into action," said WHO chief Tedros Adhanom Ghebreyesus.

"Countries now have clear, evidence-based recommendations they can put into practice immediately to protect people's cognitive health."

Because there is no cure for dementia or widely accessible treatment, the guidelines emphasized that prevention remains the most effective strategy to reduce the number of cases.

Among other things, the WHO suggested cognitive stimulation and training for adults experiencing mild cognitive impairment.

The WHO said better management of conditions like hypertension, diabetes and high cholesterol could also help reduce dementia risk.

It also recommended stronger integration of services for NCDs, mental health and brain health.

The WHO said investments in reducing dementia risk would pay dividends, with the condition estimated to cost the global economy $1.3 trillion annually—around half of which is unpaid care provided by family and friends.

"Understanding risk factors and taking action to prevent dementia can improve health and quality of life, helping people live longer, healthier and more independent lives," it said.

Key medical concepts

DementiaAlzheimer's DiseaseHigh Blood PressureMild Cognitive Impairment

Clinical categories

NeurologyHealthy agingPreventive medicineCommon illnesses & Prevention Who's behind this story?

Andrew Zinin

Master's in physics with research experience. Long-time science news enthusiast. Plays key role in Science X's editorial success. Full profile →

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