Could a few bad dietary choices worsen your next immune response?

by University of California, San Francisco

edited by Robert Egan

Robert Egan

Senior Editor

Meet our editorial team
Behind our editorial process
Editors' notes

This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

The GIST Add to Preferred Sources

Scientists have long known that diet shapes the immune system. Now, a UC San Francisco team has found that even a brief dietary change can substantially change how the body responds to skin irritation, at least in mice.

When scientists fed mice a high-fat diet for just a few days, the mice had a much worse reaction to an irritating cream. And the skin stayed on alert even after the mice returned to a low-fat diet and the inflammation cleared, responding more strongly the next time it was exposed to the cream.

The findings suggest that short-term diet may have just as much an effect as body weight when it comes to inflammation.

"Long-term dietary habits absolutely matter for health, but our study unearthed a much more real-time influence of diet," said Sagar Bapat, M.D., Ph.D., professor of pathology at UCSF and corresponding author of the paper, which appears in Nature on Oct. 28. "Breakfast, lunch, dinner—they all can have a tremendous and rapid impact on the immune system."

Separating diet from body weight

The discovery grew from laboratory experiments on obesity, led by Zewen "Owen" Jiang, Ph.D., co-first author of the paper, carried out when he was a graduate student at UCSF.

Jiang and his colleagues first raised mice on either low-fat or high-fat food pellets. Then, the scientists applied imiquimod, a cream that triggers skin inflammation, to one ear of each mouse and compared what happened between the low- or high-fat diet groups.

Obese mice habitually fed high-fat pellets had severe reactions to imiquimod, while mice fed with low-fat pellets had mild reactions.

"For many years, we've known that obesity is tied to more severe inflammation. But we wanted to know whether it was the extra weight or simply the bad diet that was driving the stronger response," Jiang said.

Four days changed the immune response

So, the team tested whether just four days on high-fat food was enough to trigger an overactive immune response. They switched mice that had been raised on low-fat food to high-fat food and dabbed one ear with imiquimod three days later. The normal-weight mice developed severe ear inflammation just like the obese mice.

Likewise, obese mice that had been switched to normal food for just four days experienced much milder inflammation.

Skin stays primed after inflammation fades

Weeks later, after the normal-weight mice had returned to a low-fat diet and their inflammation had subsided, they got a second dose of imiquimod in the same ear that had flared before—and it triggered an outsized response.

Jiang and Bapat found that high-fat food drew rapid-response immune cells into the skin, where they amplified the reaction to imiquimod. As the inflammation subsided, other immune cells, called memory T cells, remained in the affected ear. Together, these changes left the tissue primed for the next time.

The team found a similar kind of heightened inflammation in response to irritation in the lungs after just a few days of eating a high-fat diet.

"The diet of a laboratory mouse doesn't map neatly onto what we eat, but it's striking how quickly the immune system responds to what's happening in the body right now," said Jiang. "Diet, exercise, sleep—they could all shape immune health in ways we don't yet appreciate."

Publication details

Zewen Jiang et al., Diet at disease onset determines tissue inflammatory memory, Nature (2026). DOI: 10.1038/s41586-026-11181-4

Journal information: Nature

Key medical concepts

Diet, High-FatDermatitisImiquimodMemory T Cells

Clinical categories

Nutrition & Healthy eatingAllergy and immunologyHealthy living Provided by University of California, San Francisco Who's behind this story?

Robert Egan

Bachelor's in mathematical biology, Master's in creative writing. Well-traveled with unique perspectives on science and language. Full profile →

Citation: Could a few bad dietary choices worsen your next immune response? (2026, October 29) retrieved 30 October 2026 from https://medicalxpress.com/news/2026-10-bad-dietary-choices-worsen-immune.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.