Brazilian study links TP53 mutations to poor lung cancer prognosis

The study evaluated the 20 main genes associated with lung cancer in tumor samples from 1,131 patients treated at Hospital de Amor in Barretos and Porto Velho, in the Amazonian state of Rondônia. One of the distinguishing features of the study was the sample size and diversity of patients, who came from all five of the country's macroregions, including a significant portion from the Western Amazon, which remains underrepresented in research. This allowed for the observation of regional variations and enabled an investigation into the influence of genetic ancestry in the country.

According to Reis, this type of analysis broadens the applicability of the results and helps guide medical decisions that are more aligned with the actual routine of public health services.

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Additionally, Reis highlights that the study opens up new avenues of research. About 12% of the evaluated patients did not have known genetic mutations, suggesting the existence of other genes involved in cancer development that have not yet been identified. "The next step is to expand the study to include the entire genome to identify other genes and understand what happens in these cases," he says.

Source:

São Paulo Research Foundation (FAPESP)

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