Handheld breathalyzer enables precise monitoring of fat metabolism
· News-MedicalPrecise measurements outside the lab
Reproducible readings thanks to filter and app
The researchers therefore developed a filter that blocks interfering molecules, and a smartphone app that guides test subjects in real time as they exhale. "The device measures the volume of exhaled air and only takes a sample that comes from deep in the lungs after a certain time," says lead author Simone Hersberger, adding: "otherwise, every reading would be slightly different." In order for this to work, the devices are initially calibrated and adjusted to the patient's lung volume.
From basic research to product
The successful validation study is an important milestone for the researchers. "We were able to demonstrate that our device can detect slight differences in fat metabolism accurately and reliably," says ETH doctoral student Hersberger. Further studies are now intended to show whether the new measuring device can really be used to personalise therapies for metabolic disorders. In partnership with the University Children's Hospital Zurich, the researchers are currently looking at whether the hand-held device can help children with epilepsy better monitor their ketogenic diet. Other fields of application are the monitoring and optimisation of medical diets or of so-called GLP-1 therapies with weight loss jabs. Applications in amateur sports are also being considered.
The ETH spin-off Alivion AG has launched the device under the name 'Nutrion'. It is currently being deployed in international research studies and in medical facilities. To scale up further and to open up further fields of application, Alivion is seeking additional industry partners and strategic investors. "This example shows how the results of basic research can be put into practice and ultimately help society," says ETH professor Andreas Güntner.
This work is being financially supported by Innosuisse, the Vontobel Foundation and the Accentus Foundation.
Source:
Journal reference: