Prediabetes linked to substantial burden of mental health conditions

Announcing a new article publication for BIO Integration. Prediabetes has a high prevalence worldwide; however, the prevalence of mental health conditions within the population with prediabetes is not well understood. This study was aimed at determining the prevalence and incidence of insomnia, fatigue, anxiety, and depression among a large, real-world cohort of adults with prediabetes, and examining demographic patterns by age and sex.

This retrospective cohort analysis used data from 578,972 individuals with laboratory-confirmed prediabetes (HbA1c 5.7%-6.4%) in the TriNetX Global Collaborative Network. Outcomes were identified with ICD-10-CM codes. Prevalence was assessed over a 25-year period (2000-2025). Cumulative incidence required a 90-day washout after prediabetes diagnosis and excluded patients with prior diagnoses. Incidence rates per 1,000 person-years with 95% confidence intervals (CIs) were calculated. Analyses were stratified by age (19-39 vs. 40-65 years) and sex.

Anxiety, depression, fatigue, and insomnia were assessed among 578,972 participants with prediabetes (mean age 53 ± 11 years; 56.2% female). The overall prevalence of these conditions was 37.8% (95% CI: 37.78-37.82), 26.0% (95% CI: 25.98-26.02), 23.9% (95% CI: 23.88-23.92), and 15.7% (95% CI: 15.67-15.73), respectively. During a median follow-up of 628 days (IQR: 1,134 days), the cumulative incidence of these new-onset conditions (≥90 days after diagnosis, excluding prior cases) was 8.6% (95% CI: 8.53-8.67), 4.8% (95% CI: 4.74-4.86), 5.7% (95% CI: 5.64-5.76), and 4.0% (95% CI: 3.95-4.05), respectively.

The incidence rates per 1,000 person-years were 34.9 (95% CI: 34.54-35.26), 22.6 (95% CI: 22.31-22.89), 20.5 (95% CI: 20.26-20.74), and 12.9 (95% CI: 12.73-13.07), respectively. In stratified analyses, middle-aged adults (40-65 years) had substantially higher incidence of all outcomes than younger adults (19-39 years) (risk ratios: 0.263-0.298; all P < 0.001). Women had consistently higher incidence than men (risk ratios: 0.593-0.754; all P < 0.001). A secondary race-stratified prevalence analysis indicated that the prevalence was highest in White individuals and lowest in Asian individuals.

Mental health conditions affected more than one-third of patients with prediabetes. Middle-aged adults and women had the highest observed incidence. Routine mental health screening in prediabetes care is warranted, particularly among these high-risk demographic subgroups.

Source:

Compuscript Ltd

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