Antidepressant fluvoxamine reduces long COVID fatigue in clinical trial

31 Mar 2026, 00:34 · News-Medical

A major international trial suggests that a widely available antidepressant may help ease one of long COVID’s most disabling symptoms, bringing patients and clinicians closer to a practical treatment option.

International Long COVID Trial Design

Trial Results for Fluvoxamine and Metformin

Bayesian Adaptive Trial Innovation

Long COVID Treatment Need and Next Steps

Source:

McMaster University

Journal reference:

Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, et al. The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial. Ann Intern Med. [Epub 31 March 2026]. doi:10.7326/ANNALS-25-03959, https://www.acpjournals.org/doi/10.7326/ANNALS-25-03959