Restoring ADAR2 enzyme reduces metastatic spread in osteosarcoma

Osteosarcoma is the most common primary bone cancer in children, adolescents, and young adults. Although chemotherapy and surgery have improved survival for localized disease, outcomes remain poor when tumors spread to the lungs or return after treatment. A major challenge is that osteosarcoma cells often remain locked in an immature developmental state, allowing them to grow rapidly and invade surrounding tissues. Thus, it is necessary to identify and develop new therapeutic targets and strategies.

Source:

Bambino Gesù Children's Hospital, IRCCS

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