Gut bacteria protect mice from deadly secondary pneumonia after influenza
· News-MedicalSelect gut bacteria protect mice against post-influenza virus secondary bacterial pneumonia, according to a study published by researchers in the Institute for Biomedical Sciences at Georgia State University.
The researchers found that SFB provided marked protection against these highly lethal infections. Much of the morbidity and mortality caused by influenza pandemics results from secondary bacterial infections, suggesting that an individual's gut microbiota composition may be a pivotal factor in who survives such pandemics.
SFB's protection against post-viral secondary bacterial pneumonia was mediated by specialized immune cells called alveolar macrophages. These cells are known to become dysfunctional following influenza viral infection. While SFB resides exclusively on the outer surface of the intestine, it nonetheless epigenetically reprogrammed alveolar macrophages to resist influenza virus-induced dysfunction, thus maintaining their robust defense against respiratory bacterial pathogens.
"The intestine is normally colonized by thousands of different bacterial species but yet, incredibly, adding one more completely changes the way that lung macrophages respond to pathogens," said lead author Vu Ngo, a research assistant professor in the Institute for Biomedical Sciences at Georgia State.
Additional authors of the study include Carolin M. Lieber, Hirohito Abo, Michal Kuczma, Jun Zou and Richard K. Plemper of the Institute for Biomedical Sciences.
The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH).
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