Study uncovers mechanism driving metastasis in aggressive gastric cancer
· News-MedicalUsing 4D‑DIA quantitative proteomics and mass spectrometry, the team identified STC1 as a key downstream effector of the PVT1/EIF4A1 axis. Immunohistochemical analysis of 183 gastric cancer tissues confirmed that STC1 is markedly upregulated in tumours and correlates with lymph node metastasis, histological type and tumour stage. In mouse lung metastasis models, co‑overexpression of PVT1 and EIF4A1 produced the highest STC1 levels and the greatest number of metastatic lesions. When the researchers knocked down STC1 in cells overexpressing both PVT1 and EIF4A1, the pro‑migratory and pro‑proliferative effects were reversed, and the activation of Notch1 and EMT markers was suppressed.
The study also highlights the potential of STC1 as an auxiliary diagnostic marker. The authors note that future research should explore the tumour microenvironment's influence and integrate multi‑omics approaches to refine precision treatment strategies.
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