Study links mitochondrial health to effectiveness of anti-aging pathways
· News-Medical"The team's work shows that while reducing IGF-1 signaling is widely known to extend lifespan and protect against age-related disease in many organisms, that benefit is not universal," said Gout, who performed the bioinformatics analysis for this study and provided insight from his MSU work based on molecular evolution.
"When the integrity of mitochondrial DNA is compromised, downstream mechanisms that normally promote stress resistance and cellular repair may be blunted, effectively overriding the benefits of IGF-1 reduction. Overall, the study highlights the importance of maintaining the integrity of the mitochondrial genome for many lifespan-extending interventions to work as intended," he said.
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