Review identifies TREM-1 as key amplifier of inflammatory diseases

The review covers TREM-1's pathogenic role in sepsis, where elevated soluble TREM-1 correlates with mortality; in arthritis, where TREM-1 inhibition reduces joint inflammation; and in neurodegenerative diseases like Alzheimer's and Parkinson's, where microglial TREM-1 contributes to neuroinflammation. Several antagonists-including LR12, LP17, GF9, and the clinical-stage nanobiotide-have shown promise in preclinical models. However, the authors caution that species differences, disease heterogeneity, and risks of immunosuppression require careful optimization. They conclude that TREM-1-directed therapies hold translational potential, particularly for patients with sepsis, rheumatoid arthritis, gout, and Alzheimer's disease, and call for well-designed clinical trials to define therapeutic windows and identify responsive patient subgroups.

Source:

FAR Publishing Limited

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