A new genome-wide study uncovers evidence of the first three-way relationships between human genetic variation, variation in the fungal component of the human microbiome - known as the mycobiome - and risk of developing chronic disease.

Clinicians' ability to diagnose and treat chronic diseases is limited by scientific uncertainty around factors contributing to disease risk. A study published September 2nd in the open-access journal PLOS Biology by Drs. Emily Van Syoc, Emily Davenport, and Seth Bordenstein at The Pennsylvania State University, United States, uncovers evidence of the first ternary relationships between human genetic variation, variation in gut mycobiome, and risk of developing chronic disease.