After a year’s delay, the Ministry of Health has finally released its long-anticipated evidence brief and position statement on puberty blockers. Genspect NZ welcomes the publication, which aligns with findings from other international systematic reviews. The evidence brief confirms there is insufficient evidence to support claims that puberty blockers are safe and reversible, or that they provide mental health benefits. The studies reviewed rely heavily on subjective self-reports from adolescents and most were rated by the Ministry as having “serious” or “critical” risk of bias.