49ers vs. Cowboys prediction: Niners roll on the road in marquee matchup
· New York PostAmerica’s Game of the Week is a classic NFL rivalry game between the 49ers and Cowboys, two of the most popular franchises in the sport.
The 49ers have had much more success, both head-to-head and historically, with four straight wins against the Cowboys since 2022 and a 21-19-1 record in the series.
Oddsmakers give the road team the edge in the matchup with the spread sitting at Niners -4.
49ers vs. Cowboys prediction, best bet
The all-time series numbers between these teams mean nothing for this season, but the Cowboys would be smart to keep them in mind. Dallas is 4-5 this season and can’t afford to fall any further into a hole with the postseason race starting to take shape in the NFC.
That will be hard to avoid with the 49ers looking like the presumptive NFC winner through the first nine weeks of the season. They added DeForest Buckner to bolster their defensive line and Keenan Allen to help with an ailing receiver corps. Those moves make a dangerous team even more formidable.
The Niners have a balanced scoring attack led by Brock Purdy who ranks sixth in the NFL in passing touchdowns (17), has the league’s best QBR (81.4) and rarely takes sacks. Their running game churns out 135 yards per game (seventh-most in the NFL) and has scored the second-most touchdowns (12) in the league.
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The Cowboys defense is a train wreck. They give up 147.5 yards on the ground — only the Raiders are worse — and their secondary has allowed 16 passing touchdowns, which is tied for the fourth-most in the league.
The Cowboys have played just three games at AT&T Stadium this season, but two of their most embarrassing losses of the season came at home — an overtime collapse to the Cardinals and a blowout loss to the Buccaneers.
I’ll back the Niners to cover.
The Pick: 49ers -4 (-110, BetMGM)
Why Trust New York Post Betting
Malik Smith has been immersed in the sports betting industry since 2017. He’s a data nerd with a particular focus on the NBA and combat sports. He spends his weeknights in the winter looking for edges on plus-money NBA player props.