A new AI model enables more efficient analysis of colorectal cancer samples
· Medical Xpressedited by Lisa Lock, reviewed by Robert Egan
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Researchers at the Faculty of Information Technology at the University of Jyväskylä have used artificial intelligence to speed up the analysis of colorectal cancer samples and predict the functioning of the cells' DNA repair mechanism. The AI model's analysis can help shorten diagnosis times, reduce costs, and improve the analysis's accuracy. The research, published in Computer Methods and Programs in Biomedicine, was conducted in collaboration with the Central Finland Welfare Region.
The cell's own error-correction mechanism, the so-called MMR mechanism, corrects small errors that occur during DNA replication. If this mechanism does not function properly, it can affect both cancer development and treatment decisions.
Liisa Petäinen, who led the study at the University of Jyväskylä, explains that analyzing tissue samples is routine but time-consuming work.
"Analyzing a cancer sample in a pathology laboratory–regarding, for example, the MMR mechanism–can take several days," says Petäinen, "whereas artificial intelligence can reduce the analysis time to minutes."
Faster analysis could lead to cost savings and shorten the time it takes for a patient to receive a diagnosis and access treatment. At the same time, it would free up pathologists' time for other tasks.
Tissue surrounding the tumor also contains important information for treatment
The analysis of cancer samples is currently based on assessments by pathologists, which makes the process highly manual and time-consuming. According to Petäinen, this is precisely where AI can help.
Typically, the analysis is conducted using twentyfold magnification of the tissue sample, but the researchers also tested AI-assisted analysis using a considerably broader fivefold magnification.
The researchers have reported that the model also performed reasonably well at this scale. Petäinen is hopeful that, in the future, tissue samples could be analyzed in a single step using AI. Analyzing the entire tissue sample instead of only the tumor area would speed up screening, as the tumor area would no longer need to be identified separately in the image beforehand.
The study also suggests that tissue features surrounding the tumor may help predict the function of the repair mechanism. Analyzing the entire sample could therefore further improve the accuracy of the analysis.
The AI model was trained on patient data from a Finnish Biobank
The study was conducted together with pathologists and colorectal cancer experts from the Central Finland Biobank and the Wellbeing Services County of Central Finland. The dataset consisted of approximately 1,300 colorectal cancer patients from Central Finland. The model was also tested using data from Oulu University Hospital and the United States.
Tiina Jokela explains that Finland has high-quality biobanks, registers, and a unified health care system, which enable high-level research and faster implementation of results.
"Central Finland offers a good pilot environment where research and clinical work can collaborate flexibly," says Jokela. "The Central Hospital Nova of Central Finland provides clinical data and practical requirements for the research, while JYU provides its expertise in artificial intelligence and data analytics."
According to the researchers, new methods need to be validated using larger datasets, as was also done in this study.
More information
Liisa Petäinen et al, dMMR prediction from colorectal cancer histopathology: Leveraging non-tumor and low-magnification regions, Computer Methods and Programs in Biomedicine (2026). DOI: 10.1016/j.cmpb.2026.109317
Key medical concepts
Colorectal CancerBiological Specimen Banks
Clinical categories
OncologyLaboratory medicine Provided by University of Jyväskylä Who's behind this story?
Lisa Lock
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